Retatrutide is a synthetic investigational peptide engineered to activate three critical metabolic receptors:

• GLP-1 (Glucagon-Like Peptide-1)

• GIP (Glucose-Dependent Insulinotropic Polypeptide)

• Glucagon receptors

This triple-agonist mechanism distinguishes Retatrutide from earlier peptides that focused on only one or two metabolic pathways.